Sequel's Twiist Automated Insulin Delivery (AID) System

Sequel Med Tech’s Twiist Automated Insulin Delivery (AID) System revolutionizes diabetes care with advanced technology and a user-friendly design. In the 1970s, Dean Kamen, the inventor of AutoSyringe, the first wearable insulin pump, co-founded Sequel Med Tech. With decades of expertise, Sequel Med Tech creates innovative solutions for diabetes management. Let’s explore what makes the Twiist system unique.

What is Sequel’s Twiist AID System?

The Twiist AID system employs cutting-edge technology to provide precise insulin dosing, customizable glucose targets, and seamless integration with the iPhone and Apple Watch, making diabetes management more convenient than ever.

Specifications:

Here are the technical specifics of the Twiist system:

Weight: Lightweight and compact, under 2 ounces (56.7 grams)
Cartridge Size: Accommodates up to 300 units of insulin
Basal Rates: Customizable to meet personal needs
Bolus Delivery: Offers various options for discreet bolus delivery through the pump, iPhone, or Apple device Watch
Water Resistance: Suitable for daily use, although exact water resistance specifications are not specified

How Does It Work?

The Twiist system is the first Automated Insulin Delivery (AID) system to directly measure the volume and flow of every micro-dose of insulin delivered. The Tidepool Loop algorithm automatically adjusts insulin delivery based on readings from the Continuous Glucose Monitor (CGM) and predicted glucose levels, ensuring precise and reliable dosing for optimal glucose control.

The core of this innovation is the iiSure technology, which enhances diabetes management through advanced pressure sensors and microfluidic control. This system monitors and adjusts insulin flow in real time, reducing the risk of under- or over-delivery. It also continuously checks for blockages, leaks, or anomalies, providing immediate alerts to ensure user safety. With its precise dosing capabilities and seamless integration with glucose monitoring systems, the Twiist pump sets a new standard in reliable and efficient insulin delivery.

Target Glucose Levels

The Twiist system provides highly customizable glucose targets, ranging from 87 mg/dL to 180 mg/dL. This flexibility enables users to tailor their glucose management to fit their health goals and lifestyles.

Regulatory Approval

The Sequel Twiist AID System received FDA clearance in March 2024 for individuals with type 1 diabetes aged six and older. This clearance underscores its safety and effectiveness for a broad range of applications.

What’s Included?

The Twiist system package includes:

The Twiist insulin pump
Access to the Tidepool Loop algorithm.
Comprehensive training to ensure users feel confident operating it.

Infusion Sets

Smiths Medical Cleo 90
Unomedical Comfort
Medtronic MiniMed Silhouette
Medtronic MiniMed Quick-set

Compatibility

The Twiist AID System is designed to function with Freestyle Libre 3+ CGM, although other CGMs are expected to be added.

Mobile App and Remote Access

The Twiist system integrates seamlessly with iPhones and Apple Watches, enabling users to:

Deliver bolus doses discreetly
Monitor CGM data
Adjust insulin settings
Healthcare providers and caregivers can access user data remotely, facilitating continuous support and monitoring.

Battery Maintenance

Details regarding the battery are not specified, but the system is designed for daily wear, suggesting ease of use and maintenance.

Pros and Cons

Pros:

Innovative design with direct insulin measurement
Customizable target glucose ranges
Discreet bolus delivery via iPhone or Apple Watch
Compact and lightweight for comfortable wear
FDA clearance for children as young as 6 years old

Cons:

Limited details about CGM compatibility
Specific water resistance and battery maintenance information are not provided

Conclusion

The Twiist AID System offers a new level of precision and convenience for diabetes management. With its advanced features, customizable settings, and seamless integration with Apple devices, Twiist is a promising solution for individuals seeking greater control and simplicity in managing their diabetes. To learn more, visit Sequel Med Tech’s official website or consult your healthcare provider.